姓名：金貴善  性別：女 職稱：教授

招生類型：科學(xué)學(xué)位(碩) 科學(xué)學(xué)位(博)

招生專業(yè)：外科學(xué)（神外）(碩) 外科學(xué)（神外）(博)

研究方向：腦膠質(zhì)瘤發(fā)生機(jī)制及生物學(xué)治療研究

電子信箱：

社會(huì)任職

個(gè)人簡(jiǎn)歷

重要學(xué)術(shù)論文

1. Junwen Zhang, Jialin Wang, Mingxin Li, Xiaodong Su, Yifu Tian, Peiwen Wang, Xianzhe Zhou, Guishan Jin, Fusheng Liu*.Oncolytic HSV-1 suppresses cell invasion through downregulating Sp1 in experimental glioblastoma.Cellular Signalling.2023.103.110581.SCI

2. Xiangming Han, Qiyan Wang, Sheng Fang, Jialin Wang, Fusheng Liu, Junwen Zhang* and Guishan Jin*.P4HA1 regulates CD31 via COL6A1 in the transition of glioblastoma stem-like cells to tumor endothelioid cells.Frontiers in Oncology.2022.12.836511.SCI

3. Guidong Zhu, Junwen Zhang, Qing Zhang, Guishan Jin, Xiaodong Su, Sisi Liu, Fusheng Liu*.Enhancement of CD70?specific CAR T treatment by IFN?γ releasedfrom oHSV?1?infected glioblastoma.Cancer Immunology, Immunotherapy.2022.71（10）.2433-2448.SCI

4. Qing Zhang, Junwen Zhang, Peiwen Wang, Guidong Zhu, Guishan Jin and Fusheng Liu*.Glioma?associated mesenchymal stem cells?mediated PD?L1 expression is attenuated by Ad5?Ki67/IL?15 in GBM treatment.Stem Cell Research & Therapy.2022.13.284.SCI

5. Xiaodong Su#, Yuan Xie#, Junwen Zhang, Mingxin Li, Qing Zhang, Guishan Jin and Fusheng Liu*.HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis.Cell Death and Disease.2022.13.861.SCI

6. Qiyan Wang, Junwen Zhang*, Sheng Fang, Jialin Wang, Xiangming Han, Fusheng Liu* and Guishan Jin*.P4HA1 Down-Regulation Inhibits Glioma Invasiveness by Promoting M1 Microglia Polarization.OncoTargets and Therapy.2021.14.1771-1782.SCI

7. Junwen Zhang#, Sheng Fang#, Wenjie Song, Bo Zhang, Wenhua Fan, Guishan Jin, Fusheng Liu*.Biological Characterization and Therapeutics for Subscalp Recurrent in Intracranial Glioblastoma.OncoTargets and Therapy.2020.13.9085-9099.SCI

8. 張夢(mèng)夢(mèng)，張俊文，米蕊芳，金貴善，劉福生*.siRNA干擾BTN3A3對(duì)腦膠質(zhì)瘤細(xì)胞凋亡作用的研究.中華神經(jīng)外科雜志.2020.36（9）.951-956.核心期刊

9. 方勝, 張俊文, 董程遠(yuǎn), 田毅夫, 王啟儼, 劉福生, 金貴善*.P4HA1調(diào)控EMT影響腦膠質(zhì)瘤侵襲性研究.中國科學(xué): 生命科學(xué).2020.50（4）.446-457.核心期刊

10. Ruifang Mi, Wenhua Fan, Jiayu Ji, Chengyuan Dong, Guishan Jin, Fusheng Liu*.The enhanced efficacy of herpes simplex virus by lentivirus mediated VP22 and cytosine deaminase gene therapy against glioma.Brain Research.2020.1743.146898（1-9）.SCI

11. Bo Zhang#, Junwen Zhang#, Sheng Fang, Mengmeng Zhang, Sisi Liu, Yifu Tian, Mengjiao Ma, Fusheng Liu, Guishan Jin*.Inflammatory activation of microglia by Staphylococcus aureus caused phenotypic alterations and affected glioblastoma growth.Cell Biochem Funct.2019.1-9.DOI: 10.1002/cbf.3396.SCI

12. Wenhua Fan, Meiyu Shao, Junwen Zhang, Guishan Jin, Fu-Jian Xu,* and Fusheng Liu*.A Hybrid nanovector of suicide gene engineered lentivirus coated with bioreducible polyaminoglycosides for enhancing therapeutic efficacy against glioma.Adv. Funct. Mater..2019.29.1807104.SCI

13. 張昀昇，張俊文，米蕊芳，周益強(qiáng)，程森，宋文杰，劉福生，金貴善*.TRIM33對(duì)人腦膠質(zhì)瘤U251細(xì)胞生物學(xué)功能影響的實(shí)驗(yàn)研究.中華神經(jīng)外科雜志.2018.34（3）.292-298.核心期刊

14. Yunsheng Zhang#, Guishan Jin#, Junwen Zhang, Ruifang Mi, Yiqiang Zhou, Wenhua Fan, Sen Cheng, Wenjie Song, Bo Zhang, Mengjiao Ma, Fusheng Liu*.Overexpression of STAT1 suppresses angiogenesis under hypoxia by regulating VEGF?A in human glioma cells.Biomedicine & Pharmacotherapy.2018.104.566-575.SCI

15. 張俊文，叢曉杰，趙喬佳杰，楊霞，李夢(mèng)，陳虹，米蕊芳，金貴善，黃秉仁，劉福生*.RanBPM結(jié)合干擾素γ信號(hào)通路中的干擾素受體1.中國科學(xué) 生命科學(xué).2017.47（7）.718-727.核心期刊

16. Zhou Y, Jin G, Mi R, Zhang J, Zhang J, Xu H, Cheng S, Zhang Y, Song W, Liu F*.Knockdown of P4HA1 inhibits neovascularization via targeting glioma stem cell-endothelial cell transdifferentiation and disrupting vascular basement membrane.Oncotarget.2017.8（22）.35877-35889.SCI

17. Sen Cheng#,Ruifang Mi #, Yu Xu,Guishan Jin,Junwen Zhang, Yiqiang Zhou,Zhengguang Chen, Fusheng Liu*.Ferritin heavy chain as a molecular imaging reporter gene in glioma xenografts.J Cancer Res Clin Oncol .2017.143（6）.941-951.SCI

18. 徐恒周，金貴善，米蕊芳，張俊文，周益強(qiáng)，劉福生*.FASN在腦膠質(zhì)瘤組織中的表達(dá)及其臨床意義.中華神經(jīng)醫(yī)學(xué)雜志.2017.16（3）.217-221.核心期刊

19. 米蕊芳，金貴善，張俊文，周益強(qiáng)，徐恒周，程森，劉福生.VP22-CD基因工程化載體對(duì)膠質(zhì)瘤細(xì)胞體外殺傷作用的研究.中華神經(jīng)外科雜志.2016.6（32）.614-618.核心期刊

20. Mi RF, Pan CX, Zhou YQ, Liu YB, Jin GS*, Liu FS*.Identification of the metastasis potential and its associated genes in melanoma multinucleated giant cells using the PHA-ECM830 fusion method.Oncology reports.2016.35(1).211-218.SCI

21. 金貴善，劉福生*.醫(yī)學(xué)碩士研究生創(chuàng)新能力培養(yǎng)的分析和思考.醫(yī)學(xué)教育管理.2016.2（supp2）.118-120.核心期刊

22. 劉福生，金貴善*.對(duì)醫(yī)學(xué)專業(yè)學(xué)位碩士研究生科研能力培養(yǎng)的思考與體會(huì).醫(yī)學(xué)教育管理 .2016.2（2）.438-440.核心期刊

23. 米蕊芳，潘春曉，劉福生，張俊文，金貴善*.熒光探針及流式分選法追蹤胰腺癌細(xì)胞增殖的研究.醫(yī)學(xué)研究雜志.2016.45（5）.29-32.核心期刊

24. Zhou Y, Jin G, Mi R, Zhang J, Zhang J, Xu H, Cheng S, Zhang Y, Song W, Liu F*.Inhibition of fatty acid synthase suppresses neovascularization via regulating the expression of VEGF-A in glioma.J Cancer Res Clin Oncol.2016.142.2447-2459.SCI

25. 米蕊芳，金貴善，張俊文，周益強(qiáng)，徐恒周，程森，劉福生*.人膠質(zhì)瘤自殺基因細(xì)胞系的建立及其在膠質(zhì)瘤治療研究中的應(yīng)用.醫(yī)學(xué)研究雜志.2016.45（5）.46-49.核心期刊

26. 張晉，金貴善，米蕊芳，周益強(qiáng)，房紹偉，劉福生*.神經(jīng)膠質(zhì)瘤干細(xì)胞向內(nèi)皮細(xì)胞分化的差異基因表達(dá)譜的分析.中華神經(jīng)外科雜志.2015.31（3）.299-303.核心期刊

27. Dong C#, Mi R#, Jin G, Zhou Y, Zhang J, Liu F.Identification of the proliferative effect of Smad2 and Smad3 in TGFβ2/Smads signal pathway using RNA interference in glioma cell line.Molecular Medicine Reports.2015.12.1824-1828.SCI

28. 董程遠(yuǎn)，金貴善，米蕊芳，周益強(qiáng)，張晉，劉福生*.shRNA干擾技術(shù)對(duì)腦膠質(zhì)瘤細(xì)胞中TGFβ2/Smads通路的研究.中華神經(jīng)外科雜志.2014.30(4).404-408.核心期刊

29. 周益強(qiáng)，金貴善 米蕊芳 董程遠(yuǎn) 張晉 劉福生*.血小板源性生長(zhǎng)因子B及其基因啟動(dòng)子區(qū)甲基化在腦膠質(zhì)瘤中的表達(dá)及意義.中華神經(jīng)外科雜志 .2014.30(3).288-291.核心期刊

30. 聶秀濤，金貴善，徐厚池，劉福生*.腦膠質(zhì)瘤干細(xì)胞和血管關(guān)系的研究進(jìn)展.中華神經(jīng)外科雜志.2014.30(3).315-317.核心期刊

31. Zhang GB, Jin GS, Nie XT, Mi RF, Zhu Guidong, Liu FS*.Enhanced antitumor efficacy of an oncolytic herpes simplex virus expressing an endostatin-angiostatin fusion gene in human glioblastomas stem cell xenografts.PLOS ONE.2014.9（4）.e95872.SCI

32. Zhou YQ#, Jin GS#, Mi RF, Dong CY, Zhang J, Liu FS*.The methylation status of the platelet-derived growth factor-B gene promoter and its regulation of cellular proliferation following folate treatment in human glioma cells.Brain Research.2014.1556.57-66.SCI

33. 張國濱，金貴善，米蕊芳，周益強(qiáng)，董程遠(yuǎn)，劉福生*.內(nèi)皮抑素和血管生成抑素融合基因修飾的單純皰疹病毒對(duì)膠質(zhì)瘤干細(xì)胞殺傷作用的實(shí)驗(yàn)研究.中華神經(jīng)外科雜志.2014.30（7）.723-728.核心期刊

34. 周益強(qiáng)，金貴善，劉福生.PDGF-B在腦膠質(zhì)瘤中的研究進(jìn)展.中華神經(jīng)外科雜志.2014.30（8）.844-846.核心期刊

35. 米蕊芳，劉福生，金貴善*.多核巨細(xì)胞對(duì)小鼠黑色素瘤細(xì)胞轉(zhuǎn)移能力的研究.中華臨床醫(yī)師雜志.2013.7(14).6457-6461.核心期刊

36. 聶秀濤，金貴善，米蕊芳，張國濱，謝堅(jiān)，曹澤，周益強(qiáng)，董程遠(yuǎn)，劉福生*.人腦膠質(zhì)瘤干細(xì)胞分化為血管內(nèi)皮細(xì)胞的實(shí)驗(yàn)研究.中華神經(jīng)外科雜志.2013.29（3）.289-293.核心期刊

37. Jin GS, Zhou YQ, Chai Q, Zhu GT, Xu FJ, Liu FS*.VP22 and cytosine deaminase fusion gene modified tissue-engineered neural stem cells for glioma therapy.J Canc Res Clin Oncol.2013.139 (3).475-483.SCI

38. Jin GS, Hao SY, Xie J, Mi RF and Liu FS*.Collision tumors of the sella: coexistence of pituitary adenoma and craniopharyngioma in the sellar region.World journal of surgical Oncology.2013.11.178（1-7）.SCI

39. 米蕊芳，劉福生，金貴善*.植物血凝素-ECM830細(xì)胞融合法融合黑色素瘤細(xì)胞.中國醫(yī)學(xué)科學(xué)院學(xué)報(bào).2013.35（5）.515-518.核心期刊

40. Jin GS, Zhu GD, Zhao ZG, Liu FS*.VP22 enhances the expression of gluco-cerebrosidase in human Gauche II fibroblast cells mediated by lentivirus vector.Clin Exp Med.2012.12(3).135-143.SCI

41. 劉福生，金貴善*.指導(dǎo)臨床醫(yī)學(xué)科研型碩士研究生發(fā)表SCI論文.首都醫(yī)科大學(xué)學(xué)報(bào)社科版.2012.增刊.355-357.核心期刊

42. 曹澤、金貴善、劉福生*、謝堅(jiān).TGF-β2/Smad2 在人腦膠質(zhì)瘤組織中的表達(dá)及意義.中華臨床醫(yī)師雜志.2012.6（6）.43-46.核心期刊

43. 金貴善，劉福生*.培養(yǎng)科研型碩士研究生的科研思維.首都醫(yī)科大學(xué)學(xué)報(bào)社科版.2012.增刊.353-354.核心期刊

44. Zhu GD, Su W，Jin GS, Xu FJ, Hao SY, Guan FX, Jia W, Liu FS*.Glioma stem cells targeted by oncolytic virus carrying endostatin-angiostatin fusion gene and the expression of its exogenous gene in vitro.Brain Research.2011.1390.59-69.SCI

45. 蘇偉，朱貴東，劉福生*，姜中利，金貴善，柴奇，曹澤，聶秀濤.Smad2基因在人腦膠質(zhì)瘤的表達(dá)及其臨床意義.中華神經(jīng)外科雜志.2011.27（10）.1064-1068.核心期刊

46. 蘇偉，劉福生*，朱貴東，姜中利，金貴善，柴奇，曹澤.人腦膠質(zhì)瘤中轉(zhuǎn)化生長(zhǎng)因子β2、Smad3蛋白表達(dá)及臨床意義.中國康復(fù)理論與實(shí)踐.2011.17（5）.433-436.核心期刊

47. 朱貴東，劉福生*，蘇偉，金貴善，柴奇.內(nèi)皮抑素和血管生成抑素融合基因修飾的單純皰疹病毒對(duì)膠質(zhì)瘤干細(xì)胞的體外實(shí)驗(yàn)研究.中華神經(jīng)外科雜志.2011.27（9）.949-954.核心期刊

48. 金貴善, 劉福生* ,柴奇, 蘇偉 ,朱貴東.VP22修飾的CD基因工程化干細(xì)胞治療大鼠C6腦膠質(zhì)瘤體外實(shí)驗(yàn)研究.中華神經(jīng)外科雜志.2009.25(11).1039-1043.核心期刊

49. 金貴善，劉福生*，柴奇，蘇偉，朱貴東.慢病毒載體VP22-EGFP的構(gòu)建及其對(duì)大鼠神經(jīng)干細(xì)胞轉(zhuǎn)染及表達(dá)的研究.中華神經(jīng)外科雜志.2009.25 (3).278-282.核心期刊

50. Jin GS, Liu FS*, Chai Q, Wang JJ, Li JH.Stable EGFP gene expression in C6 glioma cell line after transduction with HIV-based lentiviral vector.Chin J Cancer Res.2008.20.243-248.SCI

51. 王建交，楊立莊，劉福生* ，金貴善， 柴奇.內(nèi)皮抑素和血管生成抑素融合基因的裂解病毒對(duì)C6膠質(zhì)瘤的實(shí)驗(yàn)研究.中華神經(jīng)外科雜志.2008.24（1）.69-72.核心期刊

52. Jin GS, Liu FS*, Chai Q, Li JH.Fusions of dendritic cells transfected with TGF-β1 antisense in treatment of intracranial gliomas.Chin J Cancer Res.2007.19.113-118.SCI

53. 金貴善，劉福生*，柴奇，王建交，車樹圣.慢病毒介導(dǎo)的穩(wěn)定表達(dá)綠色熒光蛋白的C6膠質(zhì)瘤細(xì)胞株的建立及其生物學(xué)特性的觀察.中華神經(jīng)外科雜志.2007.23.541-544.核心期刊

主編或副主編的著作/譯著

1. 《腦膠質(zhì)瘤基礎(chǔ)與臨床研究》,主編,人民衛(wèi)生出版社,201603

重要獎(jiǎng)項(xiàng)

1. 腦膠質(zhì)瘤化學(xué)治療和生物治療的研究 山東省科學(xué)技術(shù)進(jìn)步獎(jiǎng) 二等獎(jiǎng) 2013

2. 腦膠質(zhì)瘤化學(xué)治療和生物治療的實(shí)驗(yàn)研究 華夏醫(yī)學(xué)科技獎(jiǎng) 三等獎(jiǎng) 2012